[quote=@Phoenix]
I'd meant to bring this up earlier, but other things grabbed my attention xP
I agree, I think it should generally be 3-5 miles for a route. Cities are more along the size/population suggested in the anime/manga. 
But I'd like to bring up the fact that traveling off route (so the forest between Route 119 and 120 (south of Fortree City)) to be open for travel (the same goes for all other areas the game cannot take you). It'd be more wild and thickly forested, so it's not travel friendly (hence the purpose of Routes). For example, a character I made for this lives in a cabin north of Petalburg City and Route 102. These areas can be given their own names (like instead of Petalburg Woods, it could be Petalrusturf Forest (as the crudest of example names)). But that would, more or less, be up for everyone to contribute towards should the want or need arise.

I just had a thought, however. Since no one's really exploring Gyms and such, would everyone be okay with my establishing their locations, and possibly leaders? It would just give everyone the chance to be able to seek out a seasoned trainer or the possibility of interacting with them should the want arise.
[/quote]

Shouldn't the region correspond more or less to the region of Japan it's based on? The way I remember it from the anime, there seemed to be a good distance between the major cities, and a lot more little towns and villages than the few showcased in the games.

The distances could certainly be condensed from real life, but I think something more realistic and still manageable would be around 30km for each route. A day's travel on foot per route, basically. Much less than a day on a bike, and chump change when you're flying. On a case by case basis (say Verdanturf/Mauville or Littleroot/Oldale) the in-game routes could be subroutes of 25km or less, but if you condense it as you say here, Hoenn (including the sea half) would be smaller than Luxembourg. The real Kyushu is nearly 15 times that size.

[hider=Kyushu]
[img]https://upload.wikimedia.org/wikipedia/commons/4/4f/Kyushumap-en.png[/img]
[/hider]

[url=http://www.40k.zombiecrisis.org/map-hoenn.png]Hoenn map focused on Routes[/url]