[@Regitnui] "alternate Universe" means they don't exist and never have existed.
Z-moves aren't too exciting. I'd say they can be trained to have super powerful (other) moves through training. I don't know, what do you think?
Edit: Actually, same status as mega evolution.
Realistic collateral damage as per Pokèmon's power. Death can (and will) occur. Humans can be paralyzed/poisoned/burned/etc. Humans are affected much more severely by Pokèmon attacks. Berries still have affects on humans, but they are generally muted/need to have a concentrated form of berries to be effective (most human medicine is a super condensed, sometimes synthetic, form of berries).