[@thewizardguy], but surely there's a certain amount of disconnect? Marching House is about five foot in diameter, and not at all humanoid. He might see a girl, but he'd get a shell in the hip if he tried to step close enough to put a hand on her shoulder.

The reason I'm saying no is because a number of these powers, if nullified, are outright lethal. Spectrum would lose their armour and then be rendered helpless by agoraphobia, and anything in Traveler's portals would get Portal Cut. An Epic Skeptic, or a scientist trying to get to the bottom of powers in general, the concept is fine. 

The walking antimagic zone gives me the heebie-jeebies. Any wielder of that ability becomes the most important being in the setting by default. The Kryptonites want to recruit you and weaponize the ability, the High want to dissect you mentally, physically and temporally, and every Epic on the planet wants you either gone or dead.