[quote=@Bishop]
Without the influence of outside factors which aren't part of chemical reactions and don't follow physical laws, like supernatural things and without a higher civilization messing around with space/time and the universe in general then yeah, the universe is deterministic or predetermined as you might say.
[/quote]

Even with interference from the future, I would say that sans an infinite loop, it would still be predetermined. Pretty much, any closed system behaves the same way under the same conditions, correct?