[quote=@ihinka]
I suppose it would depend if we want the Gotham feel to our setting... Or the mysterious, magic, voodoo-y feel... which would be in my mind New Orleans 
[/quote]

Since Katrina, New Orleans has changed a lot from what it used to be. It's mostly a bad tourist trap near the Quarter and than the further you go out, really heavy slum areas. It's a lot more run down and abandoned than it used to be.

I personally think that it might be best to just create a fictional city like Gotham or Metropolis, but if we wanted to stay in the states, my vote is for Chicago or Detroit.