I just simulated me trying to shoot myself in the right eye with my right hand using my Walther P22 airsoft replica... The angle was so awkward my wrist cried out in pain. Admittedly it's my busted wrist but it would be hard to shoot yourself like this. With two hands, maybe. Even opposite arm on eye was still a bit awkward. And I would imagine it would be difficult looking at the barrel and it wouldn't do much for one's determination.