[quote=@GarlandDaHero]
Will prior knowledge of the games be required for this, or no?
[/quote]

Not really. DMC's concept boils down to "badass demon hunters fight demons", so you can pick it up quickly. And if you do have any questions about setting details, just ask away. I played the games a TON, so I can answer any question you might have.
I actually noted this in the FAQ.