Im no GM so I have no authority on this matter. Take with what I say with a grain of salt.

But I believe that there is a danger inside of the city, which had always been there since before the Hunters had been established. It’s just that the incidents have always been isolated or simply dismissed (no one really cares about what happens to vagrants in the ghettos), but even with the Hunters I believe that the situation is a bit more murky then just “people no one cares about us being attacked”.

This is meta so of course some don’t characters realize this, but I’m pretty sure even this current hunt is just to scapegoat a relatively isolated and harmless vampire colony to hide the true killers in the city, who may or may not be linked to the upper nobility (because of course). So it’s totally possible for monsters to be preying in the city without being found. And not because they’re good at covering their tracks or expert assassins, but because thy have the power to corrupt “justice”.