Resident Evil 4 had the best enemies and bosses by a country mile. Even if you liked the designs of the bosses in REmake and Zero (oh look a big verson on of an animal) the isn't much strategy in fighting them. Its a war of attration, just have enough health and ammo to tank hits and shoot them a lot.

If you want to say Resident Evil 4 had uninteresting characters, you cant then retro-actively praise Leon and Ada in 2. Either they are good characters or they arent.