Basically, I'm still developing most of these too btw so this is early concept, but there is going to be two major "npc" factions that show up, one that is lead by someone who wants their group to take over everything and rule similarly to how Tier Five did, just without that organization system of guardians or the use of the editing functions of the Systems, and one that wants to take over everything and instill a despot who doesn't really do anything and lets the System take care of itself.
Either of these two leaders can be taken up by someone but you've gotta be creative with their powers because they're incredibly OP if you just do the obvious stuff.

Then there's the other members of those groups, which there's a shitton of.