My go-to response for those kinds of questions is always: do what you think you can maintain, what you have solid ideas and directions for, and are confident with. 

But, I'll also add in that, without even needing to ask, that Superior Spider-Man isn't going to happen.
EDIT: To clarify, in case that was too abrupt and harsh. It's a year one game, and Otto's a very important Spider-figure. Both heavily preventing such an idea.