[quote=@Overlord Thraka]
I think they work better for comedic purposes than actual drama. Scoobynatural is one example of what I think is great Isekai style works. Taking Sam, Dean and Cass from Supernatural, an already humorous and 4th-wall-breaking show, and then putting them inside a Scooby-Doo cartoon was genuinely hilarious
[/quote]

It was great. I loved that episode of Scoobynatural.