Well, anyone of the older hunters are likely to know Isana, especially Shuro.

She should have a better time dealing with other people around her age that are also more on the serious side. But she should have no trouble treating a younger one like a sibling or something like this as long as they show that they aren't punks.

In essence, she behaves more or less like someone a good 30 years or so older than she's, if not more.