Sam returned to the hotel room he and his brother were currently sharing, not really caring if his brother was still upset at the fact he uprooted him from a normal life with Lisa and Ben. For them, normal was something they'd never obtain. Especially now that Sam didn't have a soul. 

"Hey, wake up, I found something in a town not too far away." He said, shaking Dean's shoulder. He walked over to grab his bag to pack up. "People have been going missing, some of them coming back drained of blood. Could be vampires."