lots, but most are stupid or inappropriate to be talking about here

I think we could legitimately do a Post Apocalyptic KOTH, wherein the cause of the apocalypse isn't really known.  It could even turn out to be basically a perfect mix of all the things people always say will end the world all at once.

We could do KOTH if it started in 2020 or 2019 or 2021 instead of like 99 or some shit.

We could do KOTH but in a Medieval Fantasy setting.

We could do KOTH but aliens invade.

We could do KOTH but Boomhauer is an FBI Agent (as hinted in teh season finale) who is actually investigating something.  Maybe Bill Dautrevie or however that name is spelled is into human trafficking or drug trafficking or some shit.