[quote=@BigPapaBelial]
Hmmmm tell me more?
[/quote]

Assuming you're already familiar with the franchise...

This would take place in some length of time following the end of SoR4. I'm leaning towards a year after. Even though the Y twins were defeated, the Syndicate lived on in the form of disjointed factions, leading to a state of gang warfare with multiple parties attempting to gain control over it and rebuild. The police are in shambles due in part to Syndicate meddling and infiltration, as well as the strain of maintaining order in an otherwise chaotic city. 

Meanwhile, the protagonists from the games have parted ways from each other. Axel Stone left the city out of shame for the fallout of their prior actions; Blaze and Adam stayed behind to attempt to regroup law enforcement against the gang wars and internal corruption while trying, at the same time, to prevent the Syndicate from returning again.