I was thinking of a legit guerrilla movement like the ones they had in Latin America during the 70s.

Are we super set on a modern setting? 70s/80s might have the realest US-backed dictatorship vibes, but modern-day most likely means more modern skyscrapers for Spider-Che to websling from. 

Also, since this setting is probably much more violent than usual I am wondering how Spidey will handle his/her no-killing rule. The guy could probably slaughter an entire platoon of soldiers in one go if he really tried hahaha

EDIT: I was also thinking of going with Vulture with a version of his Homecoming suit, or even just Venom.