[quote=@Lugubrious]
<Snipped quote by Squashedquatch>

They are, depending on their location and story relevance.
[/quote]

Ok because I am trying to decide between the shopkeep and the food lady. Food gives stats and health, and the shopkeep just sells stuff which I do not think is useful early game. I am including Haken, who gives you a free weapon before the start of the run, and Coblovina who you train your skills with as they are must-haves.