[quote=@Pirouette]
Yus. 

I already thought of how a Peter Parker or Miles would work. With the Reach’s defeat, their experimental or cosmic spider that turned Cindy into Silk, was released into the wild. 

From there, anything is possible. 
[/quote]

Clearly Peter Parker was a normal research assistant for a military project during the Reach War. During a weapons test he saved the life of a kid who wandered onto the range, he was bitten by a spider just as he was infused with a massive dose of radiation turning him into the SPIDER-HULK.

[img]https://static1.srcdn.com/wordpress/wp-content/uploads/2021/10/Spider-Man-as-Hulk.jpeg[/img]

[i]You wouldn't like him when he's feeling responsible...[/i]