My general idea for preventing spoilers as far as location goes was an incursion into a foreign and previously unknown land, or set this in a time before the settling of Calderon Valley. It's entirely likely that everyone will be playing a Cursor, or someone otherwise useful to a Cursor mission.

At the moment, I'm favoring the new land idea. None of the PCs would have the advantage of local furies, and it would be somewhat of a gritty, survival oriented experience. Perhaps this is even a land devoid of furies, leaving the PCs with only their own to use in a hostile environment.