[quote=Vortex]
Now I don't know if this is true so don't judge me by it, but I heard that one day the disease will one day become so evolved that it will have out evolved the vaccine, rendering the vaccine useless. Your thoughts?
[/quote]

That's a confirmed. Everything evolves and adapts, no reason a disease one day would not evolve to a point the vaccine fails to work.
Hell that's basically what I said above in regards to flu shots. However just as the disease evolves/changes so will the vaccines, we'd simply have to come out with new vaccines to deal with the new evolved viruses.