Yeah, that'd be good. Perhaps, since she never met the Doctor, Amy had more ambition in life. Instead of spending her life waiting, she went on and became a successful journalist at an early age, living life for the here and now. And since,supposedly, Rory became a nurse to make up for the Doctor Amy never had, maybe he'd live his life for the present too, and not in hopes of one day wooing Amy. But that 's just me spit-balling here.

As for plots and such, well I suppose it comes down to what monsters you wanna face. There's definitely more too it than that, but the monsters and locations are the two things that should be decided on first. I'm partial to Zygons, weeping angels, and vashta nerada myself.