When Wesker was in his late teens, still working on the original virus, the organization is at a standstill. The virus isn't proceeding as planned. To speed up production, they hire 5 scientists from another powerful group, hiding the truth behind what they are helping create. Wesker is partnered with a woman who is a few years older than himself. At first, he hates her, as she is quick to point out every flaw in his work, but her genius slowly warms him up to her as they work together on the virus.

A joke begins to run through the lab that the two are an item, but while they make a few random flirty jokes at times, nothing ever happens between the two, as both know she will be taking her leave with the other scientists as soon as the project is over...or so SHE thinks... Wesker is aware that the organization plans to use the 5 scientists as test subjects for the virus, but after one of the four becomes contaminated, everything comes to light.

After being bit on the wrist by her fellow scientist, Wesker is quick to put a bullet in the man's head, but can't bring himself to shoot the woman as well. Instead, he opts to cut her arm off (without her permission) at the shoulder with an emergency axe, hoping it will stop the virus from flooding into her body. She is then hurried into the medical ward where, as she recovers, he tells her the truth behind the virus. The remaining 3 scientists and she are returned to their own organization with Wesker's assistance and that was where the story between them came to an end...

When he tried to research her a few weeks later, he found her obituary instead. She was dead...and so he tried to simply forget that she ever existed...

Wesker may have taken a lava bath, but he managed an escape as he always does... Alive, but extremely weak, he restarts his operation and plans to stay under the radar until his recovery. When he learns of a new virus that could reek havoc on the world, he decides to claim it for himself to study. He hurries to the asylum in Russia where the doctors have been using it on patients. On arrival, he can tell someone else has entered before him...

Inside, he realizes that, other than the doctors all being dead and the patients contaminated by the virus, the information on the virus has been taken from the computers and all versions of it that had been sent out have been corrupted by a very powerful computer virus. Knowing the person who took the information is inside the building, he goes on the hunt, discovering them as they try to make their escape.

It is a single person, a woman, whose voice brings back memories. When he stalls to shoot, she makes a run for it and he is quick to follow.

She escapes, but Wesker is already planning to meet her again.

Elsewhere, Chris and his organization break into the woman's lab, only to learn that she is doing the complete opposite of what Wesker had. She is creating cures and succeeding far beyond what anyone else has. She is a nanobot specialist, a brain that could easily rival all others. Unfortunately, Chris can tell she isn't much of a fan of the humans of the world either, but she has her own reasons that he, and Wesker, will come to discover...

She is the turn of the tide... With her assistance, the world could be saved...or destroyed...