I really want to do something along the lines of A Series Of Unfortunate Events. I don't care if we go Canon or Original, regardless, we'd have to go AU. Incest is a definite plus. If you've never read or seen it...

Siblings find out their house was destroyed and parents killed by a mysterious fire. Each has something special that helps. (Inventor, Photographic memiry, anything really). They get put with one guardian after another but someone is after their family fortune by any means necessary. Everyone else is an idiot and can't recognize the villain even when it's proved to be him/her, so it up to the siblings to find ways to outsmart him/her.