Sam and Dean have had it rough over the years; losing their mother at young ages, trained by their father in the ways of hunting, ending the Yellow Eyed Demon at the cost of their father's life, and now dealing with an angel along with Lucifer walking the earth.

The two are trying to catch a break while trying to figure out how to put Lucifer back into the Cage when a startling surprise appears in the form of a teenage girl who happens to be the last living descent of Abraham Van Helsing. Unfortunately for her, there's a high bounty placed on her throughout the supernatural world.