I have a new pairing I really want to try out. It is basically two tourists from opposite sides of the world are holidaying in the same city and meet at a youth hostel and hit it off. They party, drink, do drugs, have a banging time, but they find themselves in trouble when they find a suspicious package and suddenly the police, bad guys, etc are after them and they have to find a way to escape the city with the package and get it to its rightful owner.
The plot is fairly open and am happy to brainstorm additional points with anyone who is interested. Please shoot me a PM :)