A movie scene greatly depends on which characters are in it. So, take a famous scene, replace one of them with a different famous character, and post how the scene would go instead.

The scene where Indiana steals the relic, only to have it stolen away from him. This time, it's Optamistic prime.

So this little shit points his revolver at him and is like "gimmie the idol monkey!"

And...you know it didn't end well for him.

The "fight with the Emperor" scene from SW: Ep 3. The part of Mace Windu is instead played by Deadpool.

Deadpool: "Ok, what the actual fuck. You cut off my hand. The whiny-ass jedi reject just cut off my..."
Emperor: "UNLIMITED POWER!!!!!" Throws Deadpool out the window with lightning.
A minute later, a senator's aid walks out of the senate building and a person hits the ground beside him.
Deadpool: "Oh, god, I can taste by own liver." Tries to stand up, but collapses. "Yep, just like I thought. Every bone in my body." Looks at aid while drooling blood. "Would you mind calling a hospital. I may need them to set a few bones so I can heal from this."