Apocalyptic Vision. I have been haunted by visions of the meteor for fifteen years. Every time I sleep, I see it crashing down upon me. My personal quest is to see for myself what lies at the heart of the crater. I must overcome whatever I find there in order to stop these nightmares.

Arcane Secrets. Forbidden lore lies in Drakkenheim. Several dark wizards living in the ruins have mastered terrible and powerful new magic. The Inscrutable Tower library stands unguarded, filled with spellbooks containing secret arcana. My personal quest is to learn these spells.

Blighted Landscape. A blight on the natural order envelops Drakkenheim, but the contamination could spread beyond the city. My personal quest is to study the unnatural phenomena found within the most corrupt places in the city: Queen’s Park Garden, the underground waterways, and the Crater’s Edge. Perhaps then I can develop a way to reverse the contamination.

Claim the Throne. Though my family has fallen on hard times, we were distantly related to the royal House von Kessel. I may have a claim to the throne of Drakkenheim. My personal quest is to search the cathedral, noble estates, and the castle for sufficient evidence to conclusively prove my inheritance. Then I will take the crown for myself.

Faction Aspirant. I believe strongly in the ideals and goals of one of the five factions: either the Amethyst Academy, the Followers of the Falling Fire, the Hooded Lanterns, the Knights of the Silver Order, or the Queen’s Men. My personal quest is to join the faction, aid their mission, climb the ranks, and rise to a high leadership position within their organization.

Family Matter. One of my family members or close friends has become mixed up with one of the factions. Perhaps they have foolishly decided to join the organization. Alternatively, they’ve been taken prisoner by the faction due to some trespass or misunderstanding. Either way, my personal quest is to bring them back home.

Find a Cure. I have a friend, family member, or loved one who was contaminated by delerium and turned into a monster. They have gone mad, and are lost somewhere in Drakkenheim. My personal quest is to locate them, then discover a way to reverse their horrific transformation.

Lost Heirloom. I used to live in Drakkenheim. My personal quest is to recover a lost heirloom from my old home, which was located somewhere in the Inner City. Perhaps the item is sentimental, valuable only to members of my family. Alternatively it may have magical properties, and I wish to use these powers to aid my own ambitions.

Monster Slayer. I wish to leave behind a heroic legacy by defeating dread beasts. My personal quest is to slay three of the greatest monsters rumored to dwell in Drakkenheim, and bring back their heads as trophies. Each must be a notable creature with a challenge rating greater than my own level when I defeat them. My allies can assist me, but I must strike the decisive blow myself!

Overwhelming Debt. I owe a tremendous debt of 10,000 gold pieces, maybe more. My personal quest is to pay it back by making a fortune in Drakkenheim collecting delerium, plunder, and completing work-for-hire. Meanwhile, I must hide from bounty hunters my creditor send to kill me.

Personal Pilgrimage. As an acolyte of the faith, my personal quest is to visit several holy places in the city and perform a sacred
ritual before the remains of the martyrs interred within each: the Cathedral of Saint Vitruvio, Saint Selina’s Monastery, and the Chapel in Castle Drakken. Through these devoted acts I will understand my place in the divine order.

Score to Settle. I have come to Drakkenheim to kill one of the faction leaders: either Archwizard Eldrick Runeweaver, Knight-Captain Theodore Marshal, Lord Commander Elias Drexel, Lucretia Mathias, or the Queen of Thieves. Perhaps I seek revenge for a past wrong.
Alternatively, I may covet their position and wish to replace them. Either way, my personal quest is to slay them.

A cure-all is actually impossible in this game per the rules. I think that must be why they didn't suggest it as a potential quest line. However, if you like the idea of learning something valuable that could save a ton of people's lives, might I direct you toward the "Blighted Landscape" quest line?

Basically, a long time ago (a thousand years plus), the world was ruled by incredibly talented sorcerers who had crossed their bloodlines with dragons. They set themselves up as gods and outlawed magic use by anyone but themselves. They were oppressive tyrants. This time in history was known as the time of the Sorcerer Kings.

Eventually these kings had a warlord of theirs rise up against them. She was a woman named Tarna who was said to be chosen by The Sacred Flame (the faceless/nameless god of a new, lawful good monotheistic religion). Her mission was to put an end to the Sorcerer Kings. Because Tara had been known as a ruthless warlord, but was turned into a holy warrior, she received the title of “The First Paladin” and her redemption story lended itself to the creed of the Sacred Flame which is that “any light, no matter how small, can lead a soul out of darkness.“

Tarna was martyred and sainted after a 12 year rebellion against the sorcerer kings. After which the people of the continent (where Drakkenheim is based) rose up in repeated rebellions that eventually led to the Sorcerer Kings losing their grip on power and fleeing the continent across the sea to unknown lands. The continent then split into the regions/countries known today, united most strongly by their shared religion of the Sacred Flame which had been instrumental in bringing about the demise of the sorcerer kings. The “old gods” while still worshipped by a few, are mostly fringe and archaic deities who have fallen silent towards mortals…if they ever spoke at all.

Fast forward to several hundred years ago.

The Scared Flame is a dominant force on the continent and their new “pope” has started issuing edicts to hunt down and oppress all mageborn children in fear of a time when the Sorcerer kings might return to power. In response, a secret society of adult mages banded together forming what would later be called “The Amethyst Academy” to protect mageborn children from identification and oppression. This secret society waged political and eventually open war with the church of The Sacred Flame until, finally, after 4 decades the two sides settled on a treaty and new set of laws called “The Edicts of Lumen”. These edicts were a series of compromises between mages, the church, and the common (magicless) man meant to balance power between them without oppression of any one side.

The edicts of Lumen keep any mageborn person from holding lands or noble title. The edicts allow the Amethyst Academey to take charge of all (incredibly rare) mageborn children and train them in magic until adulthood when they are released back into society (usually as noble advisors).

The balance of power between the church and the Amethyst Academy is tenuous, in danger of tipping at any given time. Both sides are seen to be hypocritical and underhanded in the way they treat the spirit of the Edicts of Lumen…constantly threatening to take over at the other’s expense.